Neural Orchestration of Metabolism and Islet Function

The International Group on Insulin Secretion – IGIS – was established in the late 1990s by a group of academic researchers to boost interest in islet biology and insulin secretion and to promote the dissemination of front-line research results to a wider medical public.
As a company with a long-standing interest in promoting research in diabetes, Servier provided IGIS with a long-term grant. Thanks to this support, a series of yearly closed symposia was initiated, each focusing on a central theme related to islet function in relation to type 2 diabetes. Attended by senior scientists and younger researchers, these symposia were developed into high-level meetings with an emphasis on extensive interaction.
The XVth Servier-IGIS Symposium, held on the theme “Neural Orchestration of Metabolism and Islet Function,” was another successful meeting where leading experts were able to interact and share their views of the subjects discussed at the meeting.
With a view to sharing the latest developments with scientists and clinicians working in the field of diabetes, the present Digest summarizes a range of topics covered at the symposium.

Neural Orchestration of Metabolism and Islet Function
Claude Bernard first demonstrated the involvement of the brain in the control of glucose homeostasis, and this later led to the concept and subsequent discovery of glucose-sensing mechanisms. The brain is now considered as a center of integration of incoming nutritional, hormonal, and neuronal signals, translating this information into appropriate signals out to the periphery to control energy balance and food intake.

“Neural Orchestration of Metabolism and Islet function”
I. General points on the central control of energy balance and food intake
II. Mechanisms of direct detection of nutrients and hormones by the brain
III. Gastrointestinal and vagal detection of nutrients
IV. Control of β-cell function by the brain
V. Conclusion
Lectures during IGIS meeting