Islet Inflammation

Editorial
The international Group on Insulin Secretion – IGIS – was established in the late 1990s by a group of academic researchers to boost interest in islet biology and insulin secretion, and promote the dissemination of front-line research results to a wider medical public.
Servier, as a company with a long-standing interest in promoting research in diabetes since its founding, provided IGIS with a long-term grant.
Thanks to this support, a series of yearly closed symposia was initiated, each focusing on a central theme related to islet function in relation to type 2 diabetes.
Attended by senior scientists and younger researchers, these symposia were developed into high-level meetings with an emphasis on extensive interaction.
The XIVth Servier-IGIS Symposium, on the theme “Islet Inflammation”, was another successful meeting where world leaders were able to interact and share their views of the subjects discussed at the meeting.
With a view to sharing the state of the art with diabetes-focused scientists and clinicians, the present Digest summarizes a panel of the topics covered by the Symposium.


Islet Inflammation

Autoimmunity, by inducing pancreatic-cell destruction, is currently accepted to be the major cause of type 1 diabetes (T1D), while type 2 (T2D) is associated with insulin resistance and with β-cell dysfunction, which can also lead to β-cell death. In past decades, evidence emerged that both types of diabetes are characterized by islet inflammation.
Indeed, overnutrition and insulin resistance in T2D cause β-cells to produce proinflammatory mediators that may impair β-cell function and survival and also amplify inflammation through the recruitment of immune cells to islets. Thus, T2D can also be considered to be a chronic inflammatory disease, suggesting an overlapping pathogenesis between T1D and T2D that could motivate the development of communal therapeutic targets.
During the XIVth symposium of the International Group on Insulin Secretion (IGIS), supported by an unrestricted educational grant from Servier, the most recent research findings from the foremost international specialists in the field of islet inflammation and diabetes were presented. Below are summarized selected oral presentations.

“Islet Inflammation”
I. General points on islet inflammation in diabetes
II. What are the actors in inflammation in diabetes?
III. Conclusion
References
Lectures during IGIS meeting