Endoplasmic Reticulum: ER
Unfolded Protein Response: UPR
International Group on Insulin Secretion: IGIS
Protein Kinase RNA (PKR)-like ER kinase: PERK
Inositol-Requiring protEin-1: IRE1
Activating Transcription Factor-6: ATF6
Immunoglobulin heavy-chain Binding Protein (also known as Glucose-Regulated Protein 78): BiP/GRP78
Eukaryotic translational Initiation Factor 2 alpha: eIF2 alpha
Activating Transcription Factor: ATF4
Nuclear Factor kappa B: NF-kB
Endoplasmic Reticulum Oxidoreductin: ERO1
Serine protease Site-1 Protease: S1P
Metalloprotease Site-2 Protease: S2P
WolFram Syndrome gene 1: WFS1
Von Hippel–Lindau: VHL
Hypoxia-Inducible Factor: HIF

“The Stressed Beta-Cell”
I- ER and the canonical unfolded protein response (UPR)
II- When UPR leads to cell death
III- Cellular stress in type 2 diabetes
IV- The mitochondria and cellular stress
V- Therapeutic targeting of ER dysfunction
VI- Conclusions