13th Servier-IGIS symposium

The Hyperstimulated Beta-Cell: Prelude to Diabetes?

St. Jean Cap Ferrat, 15– 18 March 2012

Thursday 15 March

Opening Lecture
Chair: Pierre Freychet (Nice)

18:30-19:10 Gary Felsenfeld (Bethesda): Epigenetic control of insulin gene transcription
19:10-19:30 Discussion

Friday 16 March

Introductory Lecture
Chair: Claes-Göran Östenson (Stockholm)

8:30-9:10 Susan E. Ozanne (Cambridge): Metabolic programming of insulin action and secretion
9:10-9:30 Discussion

Session 1: Impact of Insulin Resistance on Beta-Cell Function – Clinical Studies
Chair: Angel Nadal (Elche)

9:30-9:50 Sonia Caprio (New Haven): Islet function in obese adolescents
9:50-10:10 Discussion
10:10-10:30 Steven E.Kahn (Seattle): Interactions between genetic background, insulin resistance and beta-cell function
10:30-10:50 Discussion
10:50-11:50 Poster Session 1
11:50-12:10 Andreas Fritsche (Tübingen): Analysis of beta-cell function: impact of incretin resistance and insulin resistance
12:10-12:30 Discussion
12:30-12:50 Thomas Buchanan (Los Angeles): Impact of pregnancy on islet function
12:50-13:10 Discussion

13:10-16:00 Lunch & Free time

Session 2: Impact of Insulin Resistance on Beta-Cell Function – Experimental Studies
Chair: Jack Leahy (Burlington)

16:00-16:20 Hadi Al-Hasani (Nuthetal): Effect of diet on islet gene expression in mice
16:20-16:40 Discussion
16:40-17:00 Rudy Leibel (New York): Lisch-like, a modifier of beta-cell function that causes islet hyperactivity in db/db mice
17:00-17:20 Discussion
17:20-17:40 Coffee break
17:40-18:00 Bruce Verchere (Vancouver): Insulin resistance, IAPP, and beta-cell dysfunction
18:00-18:20 Discussion
18:20-18:40 Karim Bouzakri (Geneva): Signalling from insulin resistant muscle to the beta-cell
18:40-19:00 Discussion

Saturday 17 March

Session 3: Intrinsic Hyperstimulation of Beta-Cells
Chair: Franz Matschinsky (Philadelphia)

8:30-8:50 Benjamin Glaser (Jerusalem): Beta-cell hyperstimulation and failure in man
8:50-9:10 Discussion
9:10-9:30 Gisela Drews (Tübingen): Role of KATP channels in beta-cell resistance to insult
9:30-9:50 Discussion
9:50-10:10 Colin Nichols (St. Louis): The diabetic mouse beta-cell: Hyperstimulated may not be hyperexcited
10:10-10:30 Discussion
10:30-11:30 Poster session 2
11:30-11:50 André Herchuelz (Brussels): Beta-cell fate in defective cellular Ca regulation
11:50-12:10 Discussion
12:10-12:30 Yuval Dor (Jerusalem): Beta-cell fate in mice with activating glucokinase mutations
12:30-12:50 Discussion

12:50-16:00 Lunch & Free time

Session 4: Modulation of Beta-Cell Function by Secretory Products
Chair: Ronald Kahn (Boston)

16:00-16:20 Matthias Braun (Edmonton): Autoregulation of insulin secretion in human islets 16:20-16:40 Discussion
16:40-17:00 Allison Goldfine (Boston): Insulin positive feedback on beta-cell function
17:00-17:20 Discussion
17:20-17:40 Bernard Zinman (Toronto): Long-term effects of short-term intensified insulin treatment in type 2 diabetes: Beta-cell rest?
17:40-18:00 Discussion
18:00-18:20 Coffee break

Closing Lecture
Chair: Emmanuel VanObberghen (Nice)

18:20-19:00 Romano Regazzi (Lausanne): miRNAs in insulin action and secretion
19:00-19:20 Discussion