Archives for July 2014

07/30/2014
Papers of Interest

Today, Bo Ahren (Lund University), is highlighting 2 papers

Bo Ahren

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells.Do OH, et al. Diabetologia. 2014;57:1400-1409.
The nature of the beta-cell defect in type 2 diabetes is still not completely understood. In this new study, the authors present novel findings that the beta-cell defect in the db/db mouse model is associated with reduced calcium response to glucose in association with a reduction in syntaxin-1A. Read the full article »

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.Madiraju AK, et al. Nature. 2014 May 21. doi: 10.1038/nature13270. [Epub ahead of print]
Although metformin is an established first-line glucose-lowering therapy in type 2 diabetes, its mechanism of action has still not been established. In this article, the mechanism is shown to be suppression of gluconeogenesis in the liver through inhibition of mitochondrial glycerophosphate dehydrogenase. Read the full article »
07/07/2014
Papers of Interest

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Today, Bo Ahren (Lund University), is highlighting 2 papers:

– Do OH, et al. The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells.

– Madiraju AK, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.