The Hyperstimulated β-Cell: Prelude to Diabetes?

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Diabetes, Obesity and Metabolism © 2013 Blackwell Publishing Ltd
Supplement: The Hyperstimulated β-Cell: Prelude to Diabetes? Proceedings of the 13th Servier-IGIS Symposium, St Jean Cap Ferrat, France, 15–18 March 2012
October 2012 – Volume 14, Issue Supplement s3

EDITORIAL
The hyperstimulated β-cell: prelude to diabetes? (pages iv–viii)
Christian Boitard, Domenico Accili, Bo Ahrén, Erol Cerasi, Susumu Seino and Bernard Thorens

REVIEW ARTICLES

Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus (pages 1–11)
Z. Xu, G. M. Lefevre and G. Felsenfeld

Emerging roles of non-coding RNAs in pancreatic β-cell function and dysfunction (pages 12–21)
C. Guay, C. Jacovetti, V. Nesca, A. Motterle, K. Tugay and R. RegazziArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01654.x

MicroRNAs in pancreas development (pages 22–28)
O. Dumortier and E. Van ObberghenArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01656.x

Metabolic programming of insulin action and secretion (pages 29–39)
M. S. Martin-Gronert and S. E. OzanneArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01653.x

Islet function in obese adolescents (pages 40–45)
C. Giannini and S. CaprioArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01643.x

Interactions between genetic background, insulin resistance and β-cell function (pages 46–56)
S. E. Kahn, S. Suvag, L. A. Wright and K. M. UtzschneiderArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01650.x

Nutrition-/diet-induced changes in gene expression in pancreatic β-cells (pages 57–67)
A. Chadt, G. S. H. Yeo and H. Al-HasaniArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01640.x

Metabolic stress, IAPP and islet amyloid (pages 68–77)
J. Montane, A. Klimek-Abercrombie, K. J. Potter, C. Westwell-Roper and C. Bruce VerchereArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01657.x

Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease (pages 78–84)
P. Plomgaard, P. A. Halban and K. BouzakriArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01641.x

Impairment of GLP1-induced insulin secretion: role of genetic background, insulin resistance and hyperglycaemia (pages 85–90)
S. Herzberg-Schäfer, M. Heni, N. Stefan, H.-U. Häring and A. FritscheArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01648.x

Neurofunctional imaging of β-cell dynamics (pages 91–100)
P. E. Harris and R. L. LeibelArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01651.x

Glucose metabolism: key endogenous regulator of β-cell replication and survival (pages 101–108)
D. Dadon, S. Tornovsky-Babaey, J. Furth-Lavi, D. Ben-Zvi, O. Ziv, R. Schyr-Ben-Haroush, M. Stolovich-Rain, A. Hija, S. Porat, Z. Granot, N. Weinberg-Corem, Y. Dor and B. GlaserArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01646.x

Repair of diverse diabetic defects of β-cells in man and mouse by pharmacological glucokinase activation (pages 109–119)
Nicolai M. Doliba, Deborah Fenner, Bogumil Zelent, Joseph Bass, Ramakanth Sarabu and Franz M. MatschinskyArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01652.x

Role of KATP channels in β-cell resistance to oxidative stress (pages 120–128)
G. Drews and M. DüferArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01644.x

The diabetic β-cell: hyperstimulated vs. hyperexcited (pages 129–135)
C. G. Nichols and M. S. RemediArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01655.x

β-Cell preservation and regeneration in diabetes by modulation of β-cell Ca2+ homeostasis (pages 136–142)
A. Herchuelz, E. Nguidjoe, L. Jiang and N. PacheraArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01649.x

Autocrine regulation of insulin secretion (pages 143–151)
M. Braun, R. Ramracheya and P. RorsmanArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01642.x

Modulation of β-cell function: a translational journey from the bench to the bedside (pages 152–160)
A. B. Goldfine and R. N. KulkarniArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01647.x

Short-term intensified insulin treatment in type 2 diabetes: long-term effects on β-cell function (pages 161–166)
R. Retnakaran and B. ZinmanArticle first published online: 28 AUG 2012 | DOI: 10.1111/j.1463-1326.2012.01658.x