Conclusions

Type 2 diabetes is a pandemic disease and intensive research is ongoing in this field.
Understanding the intrinsic pathophsyiological mechanisms of the disease is essential to develop future selective therapeutic approaches. Recent advances in molecular biology and genetics have made considerable contributions to this process. It is now obvious that though the development of insulin resistance is necessary for the onset of type 2 diabetes, the progressive decline in insulin secretion is one of the key elements of the disease. Central to this process is the functioning of the pancreatic beta-cell. Preventing loss of beta-cell mass and function, prolonging beta-cell survival, enhancing beta-cell regeneration, and controlling factors causing beta-cell damage are some of the many potential therapeutic approaches that researchers have presented at the Xth IGIS symposium. The results of this research, though giving a complicated picture of type 2 diabetes, nevertheless do shed light upon future therapeutic strategies that are likely to improve the clinician’s treatment and management of patients.

I- Regulation and maintenance of beta-cell mass
II – Regulation and production of insulin
III- Factors underlying beta-cell dysfunction in type 2 diabetes
IV- New tools in research and their clinical interest
Conclusions
References