Maintaining Optimal Beta-cell Mass for Normal Metabolism

Proceedings of the Ninth Servier-IGIS Symposium, St Jean Cap Ferrat, France, 6–9 March 2008.

This Symposium and the publication of the present supplement have been made possible by an unrestricted educational grant from Servier, Paris.

Editorial

Pancreatic beta-cell mass or beta-cell function? That is the question!
Jean-Claude Henquin, Erol Cerasi, Suad Efendic, Donald F. Steiner, Christian Boitard
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:1-4.

Original Articles

Cardiovascular cell therapy and endogenous repair
D. A. Taylor, A. G. Zenovich
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:5-15.

The biology of organ size determination
B. Z. Stanger
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:16-22

Relationship between beta-cell mass and diabetes onset
A. V. Matveyenko, P. C. Butler
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:23-31

Pancreatic beta-cell mass in European subjects with type 2 diabetes
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:32-42
J. Rahier, Y. Guiot, R. M. Goebbels, C. Sempoux, J. C. Henquin

Anatomical versus functional beta-cell mass in experimental diabetes
Diabetes Obes Metab. 2008 Nov;10 Suppl 4: 43-53
C. Kargar, A. Ktorza

Restoring a functional beta-cell mass in diabetes
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:54-62
D. Pipeleers, M. Chintinne, B. Denys, G. Martens, B. Keymeulen, F. Gorus

An examination of beta-cell function measures and their potential use for estimating beta-cell mass
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:63-76
S. E. Kahn, D. B. Carr, M. V. Faulenbach, K. M. Utzschneider

Beta-cell function assessment from modelling of oral tests: an effective approach
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:77-87
A. Mari, E. Ferrannini

Non-invasive detection of transplanted pancreatic islets
Diabetes Obes Metab. 2008 Nov;10 Suppl 4: 88-97
Z. Medarova, A. Moore

VMAT2 quantitation by PET as a biomarker for beta-cell mass in health and disease
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:98-108
M. Freeby, R. Goland, M. Ichise, A. Maffei, R. Leibel, P. Harris

Efforts to develop methods for in vivo evaluation of the native beta-cell mass
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:109-118
S. Schneider

Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:119-127
T. Otonkoski, M. Banerjee, O. Korsgren, L.-E. Thornell, I. Virtanen

Determinants of pancreatic beta-cell regeneration
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:128-135
A. Khalaileh, T. Gonen-Gross, J. Magenheim, T. Nir, S. Porat, S. Salpeter, M. Stolovich-Rain, A. Swisa, N. Weinberg, Y. Dor

Differential expression of cell cycle proteins during ageing of pancreatic islet cells
Diabetes Obes Metab. 2008 Nov;10 Suppl 4: 136-146
C. Hinault, J. Hu, B. F. Maier, R. G. Mirmira, R. N. Kulkarni

Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet–induced insulin resistance
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:147-156
I. Takamoto, Y. Terauchi, N. Kubota, M. Ohsugi, K. Ueki, T. Kadowaki

The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:157-169
G. Leibowitz, E. Cerasi, M. Ketzinel-Gilad

Can beta-cells be derived from exocrine pancreas?
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:170-178
L. Baeyens, L. Bouwens

Fluorescence-activated cell sorting purification of pancreatic progenitor cells
Diabetes Obes Metab. 2008 Nov;10 Suppl 4: 179-185
T. Sugiyama, S. K. Kim

Production of beta-cells from human embryonic stem cells
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:186-194
E. E. Baetge

Beta-cell development: the role of intercellular signals
Diabetes Obes Metab. 2008 Nov;10 Suppl 4: 195-200
R. Scharfmann, B. Duvillie, V. Stetsyuk, M. Attali, G. Filhoulaud, G. Guillemain

Insulitis in type 2 diabetes
Diabetes Obes Metab. 2008 Nov;10 Suppl 4:201-204
M. Böni-Schnetzler, J. A. Ehses, M. Faulenbach, M. Y. Donath

Cell therapy for type 2 diabetes: is it desirable and can we get it?
Diabetes Obes Metab. 2008 Nov;10 Suppl 4: 205-211
P. A. Halban