12th Servier-IGIS symposium

Pancreatic β-Cells and Glucagon – Neglected Metabolic Actors

St. Jean Cap Ferrat, France, 31 March – 3 April 2011

Thursday 31 March

Opening Lecture
Chair: Pierre Freychet (Nice)

18:30-19:30 Pierre Lefebvre (Liège): Milestones in glucagon research

Friday 1 April

Lecture 1
Chair: Alain Ktorza (Paris)

8:30-9:30 Andrew Leiter (Worcester): The developmental biology of entero- endocrine cells

Session 1: Birth and Death of the β-Cell
Chair: Ole D. Madsen (Gentofte)

9:30-10:10 Klaus Kaestner (Philadelphia): Gene expression profile in the developing islet
10:10-10:50 Patrick Collombat (Nice): β-Cell fate determination: role of Pax genes
10:50-11:50 Poster Session 1
11:50-12:30 Rohit Kulkarni: Role of insulin signalling in β-cell fate
12:30-13:10 Anne Clark (Oxford): Lifespan of islet cells in man vs. rodents
13:10-16:00 Lunch & Free time

Session 2: Regulation of Glucagon Expression
Chair: Daniel J. Drucker (Toronto)

16:00-16:40 David Irwin (Toronto): Molecular evolution of the glucagon and incretin genes
16:40-17:20 Jacques Philippe (Geneva): Cell-specific regulation of proglucagon expression and processing
17:20-18:00 Timothy Kieffer (Vancouver): Regulating and engineering GLP-1 and GIP production
18:00-18:20 Coffee break
18:20-19:00 Maureen Charron (New York): Overview of the glucagon receptor

Saturday 2 April

Lecture 2
Chair: Paul Robertson (Seattle)

8:30-9:30 David A. D’Alessio (Cincinnati): Role of dysregulated glucagon secretion in type 2 diabetes

Session 3: Regulation of Glucagon Secretion
Chair: Erik Gylfe (Uppsala)

9:30-10:10 Patrick Rorsman (Oxford): Glucose control of -cell function
10:10-10:50 Michael Wheeler (Toronto): Direct vs. indirect effects of glucose on glucagon secretion
10:50-11:50 Poster session 2
11:50-12:30 Jens Holst (Copenhagen): Regulation of glucagon secretion by incretins
12:30-13:10 Bernard Thorens (Lausanne): Brain glucose sensing and neural regulation of glucagon secretion
13:10-16:00 Lunch & Free time

Session 4: Role of Glucagon in Metabolism
Chair: Jean Girard (Paris)

16:00-16:40 Alan Cherrington (Nashville): Regulation of liver metabolism by glucagon
16:40-17:20 Leon S. Farhy (Charlottesville): Pancreatic network control of glucagon secretion in hypoglycemia counterregulation
17:20-18:00 Yoshitaka Hayashi (Nagoya): Metabolic impact of glucagon deficiency
18:00-18:20 Coffee break

Closing Lecture
Chair: Emmanuel Van Obberghen (Nice)

18:20-19:20 Bo Ahrén (Lund): The future of incretin- and glucagon-based treatments