“The Stressed Beta-Cell”

Saint-Jean Cap Ferrat, France, 25-28 March 2010

Thursday 25 March

P.M.

Lecture I
Chair: Pierre Freychet (Nice)

• Autophagy – From cell destruction to cell protection : Therapeutic applications
  Ana Maria Cuervo (New York)

Friday 26 March

A.M.

Lecture II
Chair: Xavier Leverve (Grenoble)

• Mitochondrial uncoupling protein 2 in beta cells
  Martin D. Brand (Cambridge)

Session I: The Mitochondria and Cellular Stress
Chair: Sigurd Lenzen (Hannover)

• Redox compartmentalization and cellular stress
  Dean P. Jones (Atlanta)
• Mitochondrial fission/fusion imbalance in neurodegenerative disease
  Ella Bossi-Wetzel (Orlando)
• The life and death of beta-cell mitochondria
  Orian Shirihai (Boston)
• Beta-cell anti-oxidative defence mechanisms
  Sheila Collins (Research Triangle Park)

P.M.

Session II: The Fundamentals of ER Stress
Chair: Sasanka Ramanadham (St. Louis)

• ER stress mechanisms – a concise overview
  David Ron (New York)
• Protein quality control in the early secretory pathway – the example of antibody production
  Roberto Sitia (Milan)
• The ER-associated degradation pathway
  Jeffrey L. Brodsky (Pittsburgh)
• The ER stress response to misfolded proinsulin expression in beta cells
  Allen Volchuk (Toronto)

Saturday 27 March

A.M.

Lecture III
Chair: R. Paul Robertson (Seattle)

• The UPR and translation attenuation – a modelling approach
  Chao Tang (San Francisco)

Session III: Cellular Stress in Type 2 Diabetes (I)
Chair: Roderick Paul Robertson (Seattle)

• Role of ER stress in hepatic insulin resistance
  Fabienne Foufelle (Paris)
• The VHL gene and beta-cell function
  Dominic J. Withers (London)
• Role of IRE-1 signalling for beta-cell survival
  Fumihiko Urano (Worcester)
• Role of autophagy in beta-cell function and mass
  Myung -Shik Lee (Seoul)

P.M.

Session IV: Cellular Stress in Type 2 Diabetes (II)
Chair: Noel Morgan (Plymouth)

• ER stress mechanisms in lipotoxic beta-cell dysfunction
  Miriam Cnop (Brussels)
• Glucose-amplification of lipotoxic ER stress via mTORC1
  Gil Leibowitz (Jerusalem)
• Role of CHOP in beta-cell stress
  Randal J. Kaufman (Ann Arbor)

Lecture IV
Chair: Nurit Kaiser (Jerusalem)

• Chemical chaperones – Future treatment of obesity/diabetes?
  Gökhan Hotamisligil (Boston)