Posts in the category News

09/10/2015

Today, Bo Ahren (Lund University), is highlighting a paper

Human islet function following 20 years of cryogenic biobanking. Jocelyn E. Manning Fox, et al. Diabetologia. 2015;58:1503-1512.Long-term preservation of islets is important both to generate a sufficient number of islets for transplantation and to allow multiple donor transplants with simplified logistics. It is also important to meet the increased demand for human islets for research purposes. Such long-term preservation may be achieved by biobanking and, in a recent article, Dr Manning Fox and collaborators showed that low-temperature biobanking offers such a possibility. …

01/30/2015

On the occasion of the 15th Servier-IGIS Symposium, some renowned experts in diabetes were interviewed.

Prof Erol CERASI, Prof Bernard THORENS, and Prof Christophe MAGNAN discuss the 2014 Servier-IGIS Symposium.

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01/30/2015

The IGIS Digest of the XVth IGIS symposium is available online !
The present Digest summarizes the topics covered by the symposium on the theme “Neural Orchestration of Metabolism and Islet Function” and reflects the latest front-line research results in that field.

12/01/2014
Papers of Interest

Today, Domenico Accili (Columbia University), is highlighting 2 papers

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid culturesRyotaro Bouchi, et al. Nature Communications 5, Article number:4242 | doi:10.1038/ncomms5242Generation of surrogate sources of insulin-producing β-cells remains a goal of diabetes therapy. While most efforts have been directed at differentiating embryonic or induced pluripotent stem (iPS) cells into β-like-cells through endodermal progenitors, we have shown that gut endocrine progenitor cells of mice can be differentiated into glucose-responsive, insulin-producing cells by ablation of transcription factor Foxo1. Read the full article »

Inhibition of …

09/12/2014
2014 Proceedings articles available online!

New: all articles of the last proceedings are available online!
 
D. Accili, B. Ahrén, C. Boitard, S. Seino, B. Thorens and E. Cerasi.
 
Supplement: Neural Orchestration of Metabolism and Islet Function. Proceedings of the 15th Servier-IGIS Symposium
Diabetes, Obesity and Metabolism. September 2014 – Volume 16, Issue S1
 

07/30/2014
Papers of Interest

Today, Bo Ahren (Lund University), is highlighting 2 papers

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells.Do OH, et al. Diabetologia. 2014;57:1400-1409.The nature of the beta-cell defect in type 2 diabetes is still not completely understood. In this new study, the authors present novel findings that the beta-cell defect in the db/db mouse model is associated with reduced calcium response to glucose in association with a reduction in syntaxin-1A. Read the full article »

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.Madiraju …

03/17/2014
Dialogue between Professor Jerry Nadler and Yumi Imai, Associate Professor, from Eastern Virginia Medical School: The therapeutic potential of 12 lipoxygenase (12LO).

Their discussion is based on the recent review article “Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease” by Drs Imai, Dobrian, Nadler and others, published in Diabetes, Obesity and Metabolism 15 (Suppl. 3): 117-119, 2013.

09/25/2013
Proceedings articles available online!

New: all articles of the last proceedings are available online!
Click here
B. Ahrén, D. Accili, C. Boitard, E. Cerasi, B. Thorens and S. Seino.
Special Issue: Islet Inflammation. Proceedings of the 14th Servier-IGIS Symposium
Diabetes, Obesity and Metabolism. September 2013 – Volume 15, Issue s3

09/11/2013
Dialogue between Professor Bo Ahrén and senior researcher Bilal Omar

Their discussion is based on the recent review article “Methods and models for metabolic assessment in mice” by Drs Pacini, Omar, and Ahrén, published in J Diabetes Res 2013 (986906).

06/27/2013
Interview with Professor Domenico Accili: The pivotal role of β-cells

Professor Domenico Accili, a renowned expert in diabetes research, discusses the complex machinery of β-cells and opportunities for new therapeutic approaches.