Archives for December 2014

12/01/2014
Papers of Interest

Today, Domenico Accili (Columbia University), is highlighting 2 papers

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid culturesRyotaro Bouchi, et al. Nature Communications 5, Article number:4242 | doi:10.1038/ncomms5242Generation of surrogate sources of insulin-producing β-cells remains a goal of diabetes therapy. While most efforts have been directed at differentiating embryonic or induced pluripotent stem (iPS) cells into β-like-cells through endodermal progenitors, we have shown that gut endocrine progenitor cells of mice can be differentiated into glucose-responsive, insulin-producing cells by ablation of transcription factor Foxo1. Read the full article »

Inhibition of …