Archives for December 2012
Diabetes. 2012 Dec 28
Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes.
Bachar-Wikstrom E, Wikstrom JD, Ariav Y, Tirosh B, Kaiser N, Cerasi E, Leibowitz G.
Endocrinology and Metabolism Service, Department of Medicine, Hadassah Medical Center, Jerusalem, Israel.
Accumulation of misfolded proinsulin in the β-cell leads to dysfunction induced by endoplasmic reticulum (ER) stress, with diabetes as a consequence. Autophagy helps cellular adaptation to stress via clearance of misfolded proteins and damaged organelles. We studied the effects of proinsulin misfolding on autophagy and the impact of stimulating autophagy on diabetes progression in Akita mice, …