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E Cerasi, D Accili, B Ahrén, C Boitard, S Seino, B Thorens, Editors.
Thirteenth Servier-IGIS Symposium: The Hyperstimulated β-Cell: Prelude to Diabetes?
Diabetes, Obesity and Metabolism. 2012;14(suppl 3).

Autophagy. 2013 Feb 4 ; 9(4)
Improvement of ER stress-induced diabetes by stimulating autophagy.
Bachar-Wikstrom E, Wikstrom JD, Kaiser N, Cerasi E, Leibowitz G.
Source:
Endocrinology and Metabolism Service; Department of Medicine; Hadassah-Hebrew University Medical Center; Jerusalem, Israel.
Abstract:
Pancreatic β-cell dysfunction is central in diabetes. The diabetic milieu may impair proinsulin folding, leading to β-cell endoplasmic reticulum (ER) stress and apoptosis, and thus a worsening of the diabetes. Autophagy is crucial for the well-being of the β-cell; however, the impact of stimulating autophagy on β-cell adaptation to ER stress is unknown. We studied the crosstalk …

Diabetes. 2012 Dec 28
Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes.
Bachar-Wikstrom E, Wikstrom JD, Ariav Y, Tirosh B, Kaiser N, Cerasi E, Leibowitz G.
Source:
Endocrinology and Metabolism Service, Department of Medicine, Hadassah Medical Center, Jerusalem, Israel.
Abstract:
Accumulation of misfolded proinsulin in the β-cell leads to dysfunction induced by endoplasmic reticulum (ER) stress, with diabetes as a consequence. Autophagy helps cellular adaptation to stress via clearance of misfolded proteins and damaged organelles. We studied the effects of proinsulin misfolding on autophagy and the impact of stimulating autophagy on diabetes progression in Akita mice, …