On the occasion of the 15th Servier-IGIS Symposium, some renowned experts in diabetes were interviewed.

Prof Erol CERASI, Prof Bernard THORENS, and Prof Christophe MAGNAN discuss the 2014 Servier-IGIS Symposium.

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The IGIS Digest of the XVth IGIS symposium is available online !
The present Digest summarizes the topics covered by the symposium on the theme “Neural Orchestration of Metabolism and Islet Function” and reflects the latest front-line research results in that field.


Today, Domenico Accili (Columbia University), is highlighting 2 papers

Domenico ACCILI

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid culturesRyotaro Bouchi, et al. Nature Communications 5, Article number:4242 | doi:10.1038/ncomms5242
Generation of surrogate sources of insulin-producing β-cells remains a goal of diabetes therapy. While most efforts have been directed at differentiating embryonic or induced pluripotent stem (iPS) cells into β-like-cells through endodermal progenitors, we have shown that gut endocrine progenitor cells of mice can be differentiated into glucose-responsive, insulin-producing cells by ablation of transcription factor Foxo1. Read the full article »

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesityPengpeng Bi, et al. Nature Medicine. 2014 20, 911–918 | doi:10.1038/nm.3615
Beige adipocytes in white adipose tissue (WAT) are similar to classical brown adipocytes in that they can burn lipids to produce heat. Thus, an increase in beige adipocyte content in WAT browning would raise energy expenditure and reduce adiposity. Here we report that adipose-specific inactivation of Notch1 or its signaling mediator Rbpj in mice results in browning of WAT and elevated expression of uncoupling protein 1 (Ucp1), a key regulator of thermogenesis. Read the full article »